Productos naturales bioactivos

Toxicidad de las especies reactivas de oxígeno

Estrés oxidativo en salud humana

Algunas de las publicaciones WOS que hemos desarrollado en los últimos años:

• Francisco Yanez-Lemus, Rubén Moraga, Luis Mercado, Carlos Jara-Gutierrez, Carlos T. Smith, Paulina Aguayo, Kimberly Sanchez-Alonzo, Apolinaria García-Cancino, Ariel Valenzuela, Victor L. Campos. 2022. Selenium Nanoparticles Biosynthesized by Pantoea agglomerans and Their Effects on Cellular and Physiological Parameters in the Rainbow Trout Oncorhynchus mykiss. Biology. 11(463):1-20.

• Marco Mellado, Mauricio Reyna-Jeldes, Caroline Weinstein-Oppenheimer, Claudio Coddou, Carlos Jara-Gutierrez, Joan Villena, Luis F. Aguilar. 2021. Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study. Natural Product Research. https://doi.org/10.1080/14786419.2021.1984465.

• Paula Andrea Santana, Carlos Jara-Gutiérrez, Marco Mellado, Juan Carlos Forero, Fanny Guzmán, Andrés Barriga, Fernando Albericio, Claudio Andrés Álvarez. 2021. Effects of elderflower extract enriched with polyphenols on antioxidant defense of salmon leukocytes. Electronic Journal of Biotechnology. https://doi.org/10.1016/j.ejbt.2021.04.004.

• Iván Montenegro, Jorge Moreira, Ingrid Ramírez, Fernando Dorta, Elizabeth Sánchez, Juan Felipe Alfaro, Manuel Valenzuela, Carlos Jara-Gutiérrez, Ociel Muñoz, Matias Alvear, Enrique Werner, Alejandro Madrid, Joan Villena and Michael Seeger. 2021. Chemical Composition, Antioxidant and Anticancer Activities of Leptocarpha rivularis DC Flower Extracts. Molecules. 26, 67 (https://dx.doi.org/10.3390/molecules26010067).

• García-Campos, P., Báez-Matus, X., Jara-Gutiérrez, C., Paz-Araos, M., Astorga, C., Cea, LA, Rodríguez, V., Bevilacqua, JA, Caviedes, P. Y Cárdenas, AM (2020). La N- acetilcisteína reduce el estrés oxidativo de los músculos esqueléticos y mejora la fuerza de agarre en ratones Bla / J con deficiencia de disferlina. Revista internacional de ciencias moleculares , 21 (12), 4293. https://doi.org/10.3390/ijms21124293

• I. Carrasco-Wong, C. Hernández, C. Jara-Gutiérrez, O. Porras, P. Casanello, 2019. Human umbilical artery endothelial cells from Large-forGestational-Age newborn have increased antioxidant efficiency and gene expression. Journal of Cellular Physiology.

• M. Mellado1, M. Soto, A. Madrid, I. Montenegro, C. Jara-Gutiérrez, J. Villena, E. Werner, P. Godoy, L. Aguilar, 2019. In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts. BMC Complementary and Alternative Medicine. 19(53): 1-10. (DOI: 10.1186/s12906-019-2462-3).

• Alejandra Miranda-Delgado, María José Montoya, Marilyn Paz-Araos, Marco Mellado, Joan Villena, Paulina Arancibia, Alejandro Madrid, Carlos Jara-Gutiérrez, 2018. Antioxidant and anti-cancer activities of brown and red seaweed extracts from Chilean coasts. Lat. Am. J. Aquat. Res. 46(2): 301-313. (DOI: 10.3856/vol46-issue2-fulltext-6).

• Carlos Jara, Miguel Leyton, Mauricio Osorio, Viviana Silva, Francisco Fleming, Marilyn Paz, Alejandro Madrid, Marco Mellado. 2017. Antioxidant, phenolic and antifungal profiles of Acanthus mollis (Acanthaceae). Natural Product Research. 1-4 (http://dx.doi.org/10.1080/14786419.2017.1299726).

• H. Gaete, N. Moyano, C. Jara, R. Carrasco, G. Lobos, M. Hidalgo. 2016. Assessment oxidative stress biomarkers and metal bioaccumulation in macroalgae from coastal areas with mining activities in Chile. Environ. Monit. Assess. 188:25 (DOI 10.1007/s10661-015-5021-5).

• M. Leyton, M. Mellado, C. Jara, I. Montenegro, S. Gonzalez, A. Madrid. 2015. Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum. Open Life Sci. 10: 256–264.

• M. Mellado, C. Jara, D. Astudillo, J. Villena, P. Reveco, F. Thomet. 2015. Oxaliplatin analogues with carboxy derivatives of boldine with enhanced antioxidant activity. Bioinorganic Chemistry and Applications (http://dx.doi.org/10.1155/2015/920143).

• C. Jara G., H. Gaete O., G. Lobos V., M. E. Hidalgo L. 2014. Evaluation of oxidative stress in the mollusk Echinolittorina peruviana (Gasteropoda: Littorinidae, Lamarck, 1822), in coastal sectors with mining activity. Ecotoxicology, 23 (4).

• Madrid A, Espinoza L, Mellado M, Montenegro I, González C, Santander R, Villena J & Jara C. 2013. Study of the chemical composition of the resinous exudate isolated from Psoralea glandulosa and evaluation of the antioxidant properties of the terpenoids and the resin. Bol. Latinoam. Caribe Plant. Med. Aromat., 12 (4): 338-345.

• Mellado M, Madrid A, Peña-Cortés H, López R, Jara C & Espinoza L. 2013. Antioxidant activity of anthraquinones isolated from leaves of Muehlenbeckia hastulata (J.E. SM.)